By Frank J. Dixon
The Scripps examine Institute, l. a. Jolla, CA. newest findings within the box of immunology. changed define layout.
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Extra info for Advances in Immunology, Vol. 69
These findings have been challenged by a separate study. Tourigny and co-workers (1997) set out to determine the extent of DJP and V(D)JP rearrangements in each of the four immature TN thymic subsets by quantitative Southern blotting. , 1995), no TCRP rearrangements were detected in the first two subsets (CD25-CD44' and CD25+CD44+TN thymocytes). In contrast, almost 90% of all TCRP alleles were shown to exhibit DJO rearrangements at the subsequent stage (CD25+CD44-"" TN thymocytes). However, only about 10% of all alleles at this very stage exhibited a complete V(D)J rearrangement, whereas in the subsequent CD25-CD44-""" subset, 60% of all TCRP alleles had V(D)J rearrangements.
Unfortunately, the type of analysis peformed by Passoni et al. (1997) does not allow to estimate the percentage of DP thymocytes generated by this cis pathway. 2. &expressing cells or in-frame y/G rearrangements, one would expect a complete arrest of thymopoiesis at the CD25'CD44-''"" pre-T cell stage in doubly deficient mice lacking, apart from pTa or TCRP, also functional TCRG chains. , 1992b). In contrast, the percentage and absolute number of DP thymocytes was not reduced in pTa? , 1997), suggesting a third pathway to the DP stage.
Mice are therefore most likely derived from these few T N CD25'TCRaP' thymocytes. According to this view, one would expect that mature T cells in pTn? mice do not carry more than one functional V( D)JP rearrangement, which would explain the absence of cells with two TCRP chains on the cell surface, despite the fact that allelic exclusion is compromised at the level of DNA rearrangements in pTadeficient mice. MOLECULAR AND CELLULAR EVENTS IN THYMOCYTE DEVELOPMENT 45 F. LIKELY COMPONENTS OF THE PRE-TCRSIGNAL TRANSDUCTION MACHINERY 1.
Advances in Immunology, Vol. 69 by Frank J. Dixon