Download e-book for kindle: Advances in Cancer Research, Vol. 108 by George F. Vande Woude (ed.), George Klein (ed.)

By George F. Vande Woude (ed.), George Klein (ed.)

ISBN-10: 012380888X

ISBN-13: 9780123808882

Offers precious info at the intriguing and fast-moving box of melanoma research. Outstanding and unique experiences are offered on quite a few subject matters.

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Nevertheless, it should be emphasized that all HBV genotypes can lead to end-stage liver disease including cirrhosis and HCC. Most previous retrospective or case–control studies indicated that genotype C patients had more severe liver disease including cirrhosis and HCC than genotype B patients. , 2005). A community-based prospective cohort study further showed that genotype C infection was associated with the risk of HCC development 33 Recent Advances in the Research of Hepatitis B Table II Worldwide Distribution of HBV Subgenotypes HBV subgenotype A1 (Aa) A2 (Ae) B1 (Bj) B2 (Ba) B3 B4 B5 C1 (Cs) C2 (Ce) C3 C4 Distribution Asia and Africa: India, Japan, Nepal, Philippine, South Africa Europe and North America: France, Germany, Poland, United States, United Kingdom Japan China, Taiwan, Vietnam Indonesia Vietnam Philippines Southeast Asia: Bangladesh.

2 Â 104 IU/mL). Taken together, the ample evidence from these different prospective cohort studies strongly documents that the best predictor of adverse outcomes (cirrhosis, HCC and liver-related mortality) in Asian adult HBV carriers is the serum HBV DNA level at enrollment, independent of HBeAg status, baseline serum ALT level, and other risk factors. However, whether there exists a “safe” serum HBV DNA level for nonprogressive liver disease in the real world and whether this phenomenon holds true for Western HBV carriers who acquire HBV infection later in life remain to be established.

Although high serum HBV DNA level at study entry has been suggested to increase the risk of HCC in HBV carriers over time, little is known about the longitudinal course of viral load and its relationship with HCC development. , 2008a). HBV genotype and viral load were tested from 112 cases and 1031 noncases. Prediagnostic HBV DNA levels were measured in multiple samples collected from each man (total 7706 samples), taken over periods of up to 16 years before the diagnosis of HCC. The results showed that baseline viral load influenced HBV genotype-specific HCC risks and persistence of high viral load (!

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Advances in Cancer Research, Vol. 108 by George F. Vande Woude (ed.), George Klein (ed.)


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