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Schuier, F. J. , Experimental brain infarcts in cats. II. Ischemic brain edema, Stroke, 11, 593, 1980. 27. , Three openings of the blood-brain barrier produced by forebrain ischemia in the rat, Neurosci. , 149, 75, 1993. 28. Vorbrodt, A. , Dobrogowska, D. , and Lossinsky, A. , A quantitative immunocytochemical study of the osmotic opening of the blood-brain barrier to endogenous albumin, J. , 23, 792, 1994. 29. Lossinsky, A. , Vorbrodt, A. , and Wisniewski, H. , Scanning and transmission electron microscopic studies of microvascular pathology in the osmotically impaired blood-brain barrier, J.

B. and Graham, D. , Hypoxia and vascular disorders of the central nervous system, in Greenfield’s Neuropathology, Adams, J. , Corsellis, J. A. , and Duchen, L. , John Wiley & Sons, New York, 1984, 125. ©1999 CRC Press LLC 3 Immune Response and CNS Injury Norman A. 1. 2. Primary Immune Response to Antigens in the CNS . 3. 4. 1 INTRODUCTION When considering brain injury or trauma and the immune response, three questions can legitimately be asked. Can injury of the brain generate an immune response, in particular an autoimmune response?

Petito, C. , Transformation of postischemic perineuronal glial cells. I. Electron microscopic studies, J. Cereb. , 6, 616, 1986. 17. , Control of glial cell volume in anoxia. In vitro studies on ischemic cell swelling, Stroke, 18, 623, 1987. 18. Kimelberg, H. , Astrocytic edema in CNS trauma, J. Neurotrauma, 9, S71, 1992. 19. Norenberg, M. , Astrocyte responses to CNS injury, J. Neuropathol. Exp. , 53, 213, 1994. 20. Maxwell, W. , Massive astrocytic swelling in response to extracellular glutamate: a possible mechanism for posttraumatic brain swelling, Acta.

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Acceptability of Risk From Radiation - Human Spaceflight


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