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By F. Sherwood. Taylor

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Oxford University Press, Oxford, 1993. W. Rat cold water tail-flick: A novel analgesic test that distinguishes opioid agonists from mixed agonist-antagonists. Eur. J. Pharmacol. 119:23–29, 1985. , and Gero, A. Determination of the stimulusresponse relation for three alpha-adrenergic agonists on rabbit aorta. Arch. Int. Pharmacodyn. Ther. 241: 197–207, 1979. J. S. The Dose-Response Relation in Pharmacology. Springer-Verlag, New York, 1979. , and McGonigle, P. Principles in General Pharmacology. Springer-Verlag, New York, 1988.

Equieffective dose) in this broader context which includes actual or estimated concentrations or amounts per kg of body weight, per cell, per mg of protein, etc. All of these are used in this book, although some formulas will use notations that distinguish amounts from concentrations. It is therefore necessary to understand the context of these descriptions and formulas. 3 Notation In contrast to the simple symbols x and y that are commonly used in algebra and other mathematical fields, the literature in pharmacology and toxicology usually uses notation that is more suggestive of the meanings of the terms.

5. In the hyperbolic model, the constant C is the value of the dose (or concentration) that corresponds to an effect level on the curve equal to half the maximum effect. C0457_frame_C2 Page 35 Friday, May 19, 2000 12:13 AM NONLINEAR MODELS 35 simple way to determine both C and Emax. Because neither of these assumptions is true, the reciprocated points show scatter. It may therefore seem reasonable to use the linear least squares method (regression) to fit the points to a line derived this way, and, indeed, this has been done in many pharmacologic and biochemical analyses.

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A History of Industrial Chemistry by F. Sherwood. Taylor


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